Publications
2024
Structural basis for saxitoxin congener binding and neutralization by anuran saxiphilins
Zakrzewska, S.; Nixon, S.A.; Chen, Z.; Hajare, H.S.; Park. E.R.; Mulcahy, J.V.; Arlinghaus, K.M.; Neu, E.; Konovalov, K.; Provasi, D.; Leighfield, T.A.; Filizola, M.; Du Bois, J.; Minor, D.L.
bioRxiv. Preprint.
Ligand Oxidation Activates a Ruthenium(II) Precatalyst for C–H Hydroxylation
Lauridsen, P.J.; Kim, Y.J.; Marron, D.P.; Zhu, J.S.; Waymouth, R.M.; Du Bois, J.
J. Am. Chem. Soc. 2024, 146, 23067−23074.
Schwann cell-secreted PGE2 promotes sensory neuron excitability during development
Kantarci, H.; Elvira, P.D.; Thottumkara, A.P.; O’Connell, E. M.; Iyer, M.; Donovan, L.J.; Dugan, M.Q.; Ambiel, N.; Granados, A.; Zeng, H.; Saw, N. L.; Lutz, A. B.; Sloan, S.A.; Gray, E.E.; Tran, K.V.; Vichare, A.; Yeh, A.K.; Anderson, A.; Tawfik, V.L.; Du Bois, J.; Zuchero, J.B.
Cell. 2024, 187, 4690-4712.
Dual receptor-sites reveal the structural basis for hyperactivation of sodium channels by poison-dart toxin batrachotoxin
Tonggu, L.; Wisedchaisri, G.; Gamal El-Din, T.M.; Lenaeus, M.J.; Logan, M.M.; Toma, T.; Du Bois, J.; Zheng, N.; Catterall, W.A.
Nat. Comm. 2024, 15, 2306.
Behavioral control through the direct, focal silencing of neuronal activity
Elleman, A.V.; Milicic, N.; Williams, D.J.; Liu, C.J.; Haynes, A.L.; Simko, J.; Erlich, D.E.; Makinson, C.D.; Du Bois, J.
Cell Chem. Biol. 2024, 31, 1324-1335.
2023
Trifunctional Saxitoxin Conjugates for Covalent Labeling of Voltage-Gated Sodium Channels
Finkelstein, D.S.; Du Bois, J.
ChemBioChem. 2023, e202300493.
CryoEM structures of the human CLC-2 voltage gated chloride channel reveal a ball and chain gating mechanism
Xu, M.; Neelands, T.; Powers, A.S.; Liu, Y.; Miller, S.D.; Pintilie, J.; Du Bois, J.; Dror, R.O.; Chiu, M.; Maduke, M.
bioRxiv. Preprint.
2022
Definition of a saxitoxin (STX) binding code enables discovery and characterization of the anuran saxiphilin family
Chen, Z.; Zakrzewska, S.; Hajare, H.S.; Alvarez-Buylla, A.; Abderemane-Ali, F.; Bogan, M.; Ramirez, D.; O'Connell, L.A.; Du Bois, J.; Minor, D.L.
Proc. Natl. Acad. Sci. 2022, 119, e2210114119.
Differential effects of modified batrachotoxins on voltage-gated sodium channel fast and slow inactivation
MacKenzie, T.M.G.; Abderemane-Ali, F.; Garrison, C.E.; Minor, D.L.; Du Bois, J.
Cell Chem. Biol. 2022, 29, 615-624.
Chemical and Biological Tools for the Study of Voltage-Gated Sodium Channels in Electrogenesis and Nociception
Elleman, A. V.; Du Bois, J.
Chembiochem. 2022, 23, e202100625.
Lubiprostone is non-selective activator of cAMP-gated ion channels and Clc-2 has a minor role in its prosecretory effect in intestinal epithelial cells
Oak, A. A.; Chu, T.; Yottasan, P.; Chhetri, P. D.; Zhu, J.; Du Bois, J.; Cil, O.
Mol. Pharmacol. 2022, 102, 106–115.
2021
Silylpyrrole Oxidation En Route to Saxitoxin Congeners Including 11-Saxitoxinethanoic Acid
Tang, D. T. Y.; Merit, J. E.; Bedell, T. A.; Du Bois, J.
J. Org. Chem. 2021, 86, 17790–17803.
Evidence that toxin resistance in poison birds and frogs is not rooted in sodium channel mutations and may rely on “toxin sponge” proteins
Abderemane-Ali, F.; Rossen, N. D.; Kobiela, M. E.; Craig II, R. A.; Garrison, C. E.; Chen, Z.; Colleran, C. M.; O’Connell, L. A.; Du Bois, J.; Dumbacher, J. P.; Minor, D. L.
J. Gen. Physiol. 2021, 153, e202112872.
Mechanistic Guidance Leads to Enhanced Site-Selectivity in C–H Oxidation Reactions Catalyzed by Ruthenium bis(Bipyridine) Complexes
Griffin, J. D.; Vogt, D. B.; Du Bois, J.; Sigman, M. S.
ACS Catal. 2021, 11, 10479–10486.
Precise spatiotemporal control of voltage-gated sodium channels by photocaged saxitoxin
Elleman, A. V.; Devienne, G.; Makinson, C. D.; Haynes, A. L.; Huguenard, J. R.; Du Bois, J.
Nat. Comm. 2021, 12, 4171.
2020
Development and validation of a potent and specific inhibitor for the CLC-2 chloride channel
Koster, A. K.; Reese, A. L.; Kuryshev, Y.; Wen, X.; McKiernan, K. A.; Gray, E. E.; Wu, C.; Huguenard, J. R.; Maduke, M.; Du Bois, J.
Proc. Natl. Acad. Sci. 2020, 202009977.
Discovery of a Selective, State-Independent Inhibitor of NaV1.7 by Modification of Guanidinium Toxins
Pajouhesh, H.; Beckley, J. T.; Delwig, A.; Hajare, H. S.; Luu, G.; Monteleone, D.; Zhou, X.; Ligutti, J.; Amagasu, S.; Moyer, B. D.; Yeomans, D.; Du Bois, J.; Mulcahy, J. V.
Scientific Reports 2020, 10, article number 14791.
Electrochemical Ruthenium-Catalyzed C–H Hydroxylation of Amine Derivatives in Aqueous Acid
Robinson, S. G.; Mack, J. B. C.; Alektiar, S. N.; Du Bois, J.; Sigman, M. S.
Org. Lett. 2020, 22, 7060–7063.
Dynamical model of the CLC-2 ion channel reveals conformational changes associated with selectivity-filter gating
McKiernan, K. A.; Koster, A. K.; Maduke, M.; Pande, V. S.
PLOS Computational Biology 2020, 16, e1007530.
Intermolecular sp3 C-H amination for the synthesis of saturated azacycles (Org. Lett. cover article)
Betz, K. N.; Chiappini, N. D.; Du Bois, J.
Org. Lett. 2020, 22, 1687–1691.
Veratridine: A Janus-Faced Modulator of Voltage-Gated Sodium Ion Channels
Craig, R. A. II; Garrison, C. E.; Nguyen, P. T.; Yarov-Yarovoy, V.; Du Bois, J.
ACS Chem. Neurosci 2020, 11, 418–426.
C-H Functionalization Reaction Manual
West, J. G.; Morton, D.; Bedell, T. A.; Mack, J. B. C.
Sigma Aldrich / Merck KGaA 2020.
2019
Structure of the saxiphilin:saxitoxin (STX) complex reveals a convergent molecular recognition strategy for paralytic toxins
Yen, T.-J.; Lolicato, M.; Thomas-Tran, R.; Du Bois, J.; Minor, D. L., Jr.
Science Advances 2019, 5, eaax2650.
Challenges and Opportunities for Therapeutics Targeting the Voltage-Gated Sodium Channel Isoform NaV1.7
Mulcahy, J. V.; Pajouhesh, H.; Beckley, J. T.; Delwig, A.; Du Bois, J.; Hunter, J. C.
J. Med. Chem. 2019, 62, 19, 8695–8710.
Divergent Synthesis of Natural Derivatives of (+)-Saxitoxin Including 11-Saxitoxinethanoic Acid
Walker, J. R.; Merit, J. E.; Thomas-Tran, R.; Tang, D. T. Y.; Du Bois, J.
Angew. Chem. Int. Ed. 2019, 58, 1689–1693.
Mechanistic Study of Ruthenium-Catalyzed C-H Hydroxylation Reveals an Unexpected Pathway for Catalyst Arrest
Mack, J. B. C.; Walker, K. L.; Robinson, S. G.; Zare, R. N.; Sigman, M. S.; Waymouth, R. M.; Du Bois, J.
J. Am. Chem. Soc. 2019, 141, 972–980.
2018
Intermolecular sp3 C-H Amination of Complex Molecules
Chiappini, N. D.; Mack, J. B. C.; Du Bois, J.
Angew. Chem. Int. Ed. 2018, 57, 4956–4959
Site-Selective Bromination of sp3 C-H Bonds
Sathyamoothi, S.; Banerjee, S.; Du Bois, J.; Burns, N. Z.; Zare, R. N.
Chem. Sci. 2018, 9, 100–104.
Cyanthiwigin Natural Product Core as a Complex Molecular Scaffold for Comparative Late-Stage C-H Functionalization Studies
Kim, K. E.; Adams, A. M.; Chiappini, N. D.; Du Bois, J.; Stoltz, B. M.
J. Org. Chem. 2018, 83, 3023–3033.
Synthetic Studies Toward Pactamycin Highlighting Oxidative C–H and Alkene Amination Technologies
Su, J. Y.; Olsen, D. E.; Ting, S. I.; Du Bois, J.
J. Org. Chem. 2018, 83, 7121–7134.
A selective class of inhibitors for the CLC-Ka chloride ion channel
Koster, A. K.; Wood, C. A. P.; Thomas-Tran, R.; Chavan, T. S.; Alqvist, J.; Choi, K.-H.; Du Bois, J.; Maduke, M.
Proc. Natl. Acad. Sci. USA 2018, 115, 4900–4909.
Rhodium-Catalyzed C-H Amination: A Case Study of Selectivity in C-H Functionalization Reactions
Mack, J. B. C.; Bedell, T. A.; DeLuca, R. J.; Hone, G. A. B.; Roizen, J. L.; Cox. C. T.; Sorensen, E. J.; Du Bois, J.
J. Chem. Educ. 2018, 95, 2243–2248.
C-H Hydroxylation in Paralytic Shellfish Toxin Biosynthesis
Lukowski, A. L.; Ellinwood, D. C.; Hinze, M. E.; DeLuca, R. J.; Du Bois, J.; Hall, S.; Narayan, A. R. H.
J. Am. Chem. Soc. 2018, 140, 11863–11869.
2017
Ruthenium-Catalyzed C-H Hydroxylation in Aqueous Acid Enables Selective Functionalization of Amine Derivatives.
Mack, J. B. C. M.; Gipson, J. D.; Du Bois, J.; Sigman, M. S.
J. Am. Chem. Soc. 2017, 139, 9503–9506.
Mechanistic Analysis of a Copper-Catalyzed C–H Oxidative Cyclization of Carboxylic Acids.
Banerjee, S.; Sathyamoorthi, S.; Du Bois, J.; Zare, R. N.
Chem. Sci. 2017, 8, 7003–7008.
2016
Rh2(II,III) Catalysts with Chelating Carboxylate and Carboxamidate Supports: Electronic Structure and Nitrene Transfer Reactivity.
Varela-Alvarez, A.;Yang, T.; Jennings, H.; Kornecki, K. P.; Macmillan, S. N.; Lancaster, K. M.; Mack, J. B. C.; Du Bois, J.; Berry, J. F.; Musaev, D. G.
J. Am. Chem. Soc. 2016, 138, 2327–2341.
Synthesis of the Paralytic Shellfish Poisons (+)-Gonyautoxin 2, (+)-Gonyautoxin 3, and (+)-11,11-Dihroxysaxitoxin
Mulcahy, J. V.; Walker, J. R.; Merit, J. E.; Whitehead, A.; Du Bois, J.
J. Am. Chem. Soc. 2016, 138, 5994–6001.
Mutant cycle analysis with modified saxitoxins reveals specific interactions critical to attaining high-affinity inhibition of hNav1.7.
Thomas-Tran, R.; Du Bois, J.
Proc. Natl. Acad. Sci. USA 2016, 113, 5856–5861.
Manganese (II)/Picolinic Acid Catalyst System for Epoxidation of Olefins.
Moretti, R. A.; Du Bois, J.; Stack, T. D. P.
Org. Lett. 2016, 18, 2528–2531.
Inhibition of Sodium Ion Channel Function with Truncated Forms of Batrachotoxin.
Toma, T.; Logan, M. M.; Menard, F.; Devlin, A. S.; Du Bois, J.
ACS Chem. Neruosci. 2016, 7, 1463–1468.
Asymmetric Synthesis of Batrachotoxin: Enantiomeric Toxins Show Functional Divergence against Nav.
Logan, M. M.; Toma, T.; Thomas-Tran, R.; Du Bois, J.
Science 2016, 354, 865–869.
Copper-Catalyzed Oxidative Cyclization of Carboxylic Acids.
Sathyamoorthi, S.; Du Bois, J.
Org. Lett. 2016, 18, 6308–6311.
2015
An Expedient Synthesis of Maraviroc (UK-427,857) via C-H Functionalization.
Bedell, T. A.; Hone, G. A. B.; Du Bois, J.; Sorensen, E. J.
Tett. Lett. 2015, 56, 3620–3623.
Comparative Study of the Limitations in Atom-Transfer C-H Oxidations
Adams, A. M.; Du Bois, J.; Malik, H. A.
Org. Lett. 2015, 17, 6066–6069.
2014
Organocatalytic C–H hydroxylation with Oxone® enabled by an aqueous fluoroalcohol solvent system.
Adams, A. M.; Du Bois, J.
Chem. Sci. 2014, 5, 656–659.
Non-Directed Allylic C-H Acetoxylation in the Presence of Lewis Basic Heterocycles.
Malik, H. A.; Taylor, B. L. H.; Kerrigan, J. R.; Grob, J. E.; Houk, K.; Du Bois, J.; Hamann, L.; Patterson, A. W.
Chem. Sci. 2014, 5, 2352–2361.
Analyzing Site Selectivity in Rh2(esp)2-Catalyzed Intermolecular C-H Amination Reactions.
Bess, E. N.; DeLuca, R. J.; Tindall, D. J.; Oderinde, M. S.; Roizen, J. L.; Du Bois, J.; Sigman, M. S.
J. Am. Chem. Soc. 2014, 136, 5783–5789.
Visualizing Dermal Permeation of Sodium Channel Modulators by Mass Spectrometric Imaging
Eberlin, L. S.; Mulcahy, J. V.; Tzabazis, A.; Zhang, J.; Liu, H.; Logan, M. M.; Roberts, H. J.; Lee, G. K; Yeomans, D. C.; Du Bois, J.; Zare, R. N.
J. Am. Chem. Soc. 2014, 136, 6401–6405.
Saxitoxin
Thottumkara, A. P.; Parsons, W. H.; Du Bois, J.
Angew. Chem. Int. Ed. 2014, 53, 5760–5784.
Speciation and Decomposition Pathways of Ruthenium Catalysts used for Selective C-H Hydroxylation.
Flender, C.; Adams, A. M.; Roizen, J. L.; McNeil, E.; Du Bois, J.; Zare, R. N.
Chem. Sci. 2014, 5, 3309–3314.
Vicinal Diamination of Alkenes under Rh-Catalysis.
Olson, D. E.; Su, J. Y.; Roberts, D. A.; Du Bois, J.
J. Am. Chem. Soc. 2014, 136, 13506–13509.
2013
Modular Synthesis of the Pentacyclic Core of Batrachotoxin and Select Batrachotoxin Analogue Designs
Devlin, A. S.; Du Bois, J.
Chem. Sci. 2013, 4, 1059–1063.
Carbocyclization of Unsaturated Thioesters under Palladium Catalysis
Thottumkara, A. P.; Kurokawa, T.; Du Bois, J.
Chem. Sci. 2013, 4, 2686–2689.
Maleimide Conjugates of Saxitoxin as Covalent Inhibitors of Voltage-Gated Sodium Channels
Parsons, W. H.; Du Bois, J.
J. Am. Chem. Soc. 2013, 135, 10582–10585.
Selective Intermolecular Amination of C–H Bonds at Tertiary Carbon Centers
Roizen, J. L.; Zalatan, D. N.; Du Bois, J.
Angew. Chem. Int. Ed. 2013, 52, 11343–11346.
The Stanford Institute for Chemical Biology
Chen, J. K.; Du Bois, J.; Glenn, J.; Herschlag, D.; Khosla, C.
ACS Chem. Biol. 2013, 8, 1860–1861.
A 18F-Labeled Saxitoxin Derivative for in Vivo PET-MR Imaging of Voltage-Gated Sodium Channel Expression Following Nerve Injury
Hoehne, A.; Behera, D.; Parsons, W. H.; James, M. L.; Shen, B.; Borgohain, P.; Bodapati, D.; Prabhakar, A.; Gambhir, S. S.; Yeomans, D. C.; Biswal, S. Chin, F. T.; Du Bois, J.
J. Am. Chem. Soc. 2013, 135, 18012–18015.
2012
Catalytic C–H Oxidation by a Triazamacrocyclic Ruthenium Complex
McNeill, E.; Du Bois, J.
Chem. Sci. 2012, 3, 1810–1813.
Metal-Catalyzed Nitrogen-Atom Transfer Methods for the Oxidation of Aliphatic C–H Bonds
Roizen, J. L.; Harvey, M. E.; Du Bois, J.
Acc. Chem. Res. 2012, 45, 911–922.
Fluorescent Saxitoxins for Live Cell Imaging of Voltage-gated Sodium Ion Channels Beyond the Optical Diffraction Limit
Ondrus, A. E.; Lee, H.-l. D.; Iwanaga, S.; Parsons, W. H.; Andresen, B. M.; Moerner, W. E.; Du Bois, J.
Chem. Biol. 2012, 19, 902–912.
Marked Difference in Saxitoxin and Tetrodotoxin Affinities for the Human Nociceptive Voltage-gated Sodium Channel (NaV1.7)
Walker, J. R.; Novick, P.; Parsons, W. A.; McGregor, M.; Zablocki, J.; Pande, V. S.; Du Bois, J.
Proc. Natl. Acad. Sci. USA 2012, 109, 18102–18107.
Capturing Fleeting Intermediates in a Catalytic C–H Amination Reaction Cycle
Perry, R. H.; Cahill III, T. J.; Roizen, J. L.; Du Bois, J.; Zare, R. N.
Proc. Natl. Acad. Sci. USA 2012, 109, 18295–18299.
A Designed Inhibitor of a CLC Antiporter Blocks Function Through a Unique Binding Mode
Howery, A. E; Elvington, S.; Abraham, S. J.; Choi, K.-H.; Philips, S.; Ryan, C. M.; Sanford, R. L.; Simpson-Dworschak, S.; Almqvist, J.; Tran, K.; Chew, T. A.; Zachariae, U.; Andersen, O. S.; Whitelegge, J.; Matulef, K.; Du Bois, J.; Maduke, M.
Chem. Biol. 2012, 19, 1460–1470.
Synthesis of Differentially Substituted 1,2-Diamines through Advances in C-H Amination Technology
Olson, D. E.; Roberts, D. A.; Du Bois, J.
Org. Lett. 2012, 14, 6174–6177.
2011
Rhodium-Catalyzed C–H Amination – An Enabling Method for Chemical Synthesis
Du Bois, J.
Org. Process Res. Dev. 2011, 15, 758–762.
Synthesis and Reactivity of Unique Heterocyclic Structures en route to Substituted Diamines
Olson, D. E.; Maruniak, A.; Malhotra, S.; Trost, B. M.; Du Bois, J.
Org. Lett. 2011, 13, 3336–3339.
A Diruthenium Catalyst for Selective, Intramolecular Allylic C–H Amination: Reaction Development and Mechanistic Insight Gained Through Experiment and Theory
Harvey, M. E.; Musaev, D. G.; Du Bois, J.
J. Am. Chem. Soc. 2011, 133, 17207–17216.
2010
Metal-Catalyzed Oxidations of C–H to C–N Bonds.
Zalatan, D. N.; Du Bois, J.
Top. Curr. Chem. 2010, 292, 347–378.
Ruthenium-Catalyzed Hydroxylation of Unactivated 3° C–H Bonds
McNeill, E.; Du Bois, J.
J. Am. Chem. Soc. 2010, 132, 10202–10204.
2009
Oxidative Cyclization of Sulfamate Esters Using NaOCl – A Metal-Mediated Hoffman-Löffler-Freytag Reaction
Zaltan, D. N.; Du Bois, J.
Synlett (cluster on C–H activation) 2009, 143–146.
A Mechanistic Analysis of the Rh-Catalyzed Intramolecular C–H Amination Reaction
Williams Fiori, K.; Espino, C. G.; Brodsky, B. H.; Du Bois, J.
Tetrahedron (special edition honoring Tetrahedron Young Investigator) 2009, 65, 3042–3051.
Asymmetric Synthesis of Diamine Derivatives via Sequential Palladium and Rhodium Catalysis
Trost, B. M.; Malhotra, S.; Olson. D. E.; Maruniak, A.; Du Bois, J.
J. Am. Chem. Soc. 2009, 131, 4190–4191.
Synthesis of 1,3-Diamines Through Rhodium-Catalyzed C–H Insertion
Kurokawa, T.; Kim, M.; Du Bois, J.
Angew. Chem. Int. Ed. 2009, 48, 2777–2779.
A Stereoselective Synthesis of the Bromopyrrole Natural Product (–)-Agelastatin A
Wehn, P. M.; Du Bois, J.
Angew. Chem. Int. Ed. 2009, 48, 3802–3805.
C–H Hydroxylation Using a Heterocyclic Catalyst and Aqueous H2O2
Litvinas, N. D.; Du Bois, J.
Angew. Chem. Int. Ed. 2009, 48, 4513–4516.
Understanding the Differential Performance of Rh2(esp)2 as a Catalyst for C–H Amination
Zalatan, D. N.; Du Bois, J.
J. Am. Chem. Soc. 2009, 131, 7558–7559.
De Novo Synthesis of Modified Saxitoxins for Sodium Ion Channel Study
Andresen, B. A.; Du Bois, J.
J. Am. Chem. Soc. 2009, 131, 12524–12525.
2008
Discovery of Potent CLC Chloride Channel Inhibitors
Matulef, K.; Howery, A. E.; Tan, L.; Kobertz, W. R.; Du Bois, J.; Madduke, M.
ACS Chem. Bio. 2008, 3, 419–428.
A Chiral Rhodium Carboxamidate Catalyst for Enantioselective C–H Amination
Zalatan, D. N.; Du Bois, J.
J. Am. Chem. Soc. 2008, 130, 9220–9221.
Catalytic C–H Amination for the Preparation of Substituted 1,2-Diamines
Olson, D. E.; Du Bois, J.
J. Am. Chem. Soc. 2008, 130, 11248–11249.
A Stereoselective Synthesis of (+)-Gonyautoxin 3
Mulcahy, J. V.; Du Bois, J.
J. Am. Chem. Soc. 2008, 130, 12630–12631.
2007
Catalytic Intermolecular Amination of C–H Bonds: Method Development and Mechanistic Insights
Williams Fiori, K.; Du Bois, J.
J. Am. Chem. Soc. 2007, 129, 562–568.
(+)-Saxitoxin: A First and Second Generation Stereoselective Synthesis
Fleming, J. J.; McReynolds, M. D; Du Bois, J.
J. Am. Chem. Soc. 2007, 129, 9964–9975.
γ-Sultone Formation Through Rh-Catalyzed C–H Insertion.
Wolckenhauer, S. A.; Devlin, A. S.; Du Bois, J.
Org. Lett. 2007, 9, 4363–4366.
C–H Amination in Synthesis: An Approach to the Assembly of the B/C/D Ring System of Aconitine
Conrad, R. M.; Du Bois, J.
Org. Lett. 2007, 9, 5465–5468.
2006
Expanding the Substrate Scope of C–H Amination Reactions: Oxidative Cyclization of Urea and Guanidine Derivatives
Kim, M.; Mulcahy, J. V.; Espino, C. G.; Du Bois, J.
Org. Lett. 2006, 8, 1073–1076.
A Synthesis of (+)-Saxitoxin
Fleming, J. J.; Du Bois, J.
J. Am. Chem. Soc. 2006, 128, 3926–3927.
Rh-Catalyzed Alkene Oxidation: A Highly Efficient Process for Preparing N-Alkoxysulfonyl Aziridines
Guthikonda, K.; Wehn, P. M.; Caliando, B. J.; Du Bois, J.
Tetrahedron (special edition honoring Tetrahedron Young Investigator) 2006, 62, 11331–11342.
Entrapment of a Dirhodium Tetracarboxylate Unit Inside the Aromatic Bowl of a Calix[4]arene: Unique Catalysts for C–H Amination
Brodsky, B. H.; Du Bois, J.
Chem. Comm. 2006, 4715–4717.
2005
In Modern Rhodium-Catalyzed Organic Reactions
Espino, C. G.; Du Bois, J.
Ed.: P. A. Evans, Wiley-VCH Verlag, Weinheim 2005, pp 379–416.
Rhodium Catalyzed C–H Amination: Versatile Methodology for the Selective Preparation of Amines and Amine Derivatives
Du Bois, J.
Chemtracts. Org. Chem. 2005, 18, 1–13.
Exploring New Uses for C–H Amination: Ni-Catalyzed Cross Coupling of Cyclic Sulfamates
Wehn, P. M.; Du Bois, J.
Org. Lett. 2005, 7, 4685–4688.
Oxaziridine-Mediated Hydroxylation of Unactivated 3° C–H Bonds Using Hydrogen Peroxide
Brodsky, B. H.; Du Bois, J.
J. Am. Chem. Soc. 2005, 127, 15391–15393.
2004
Deacylative Oxidation Strategy for the Preparation of a-Functionalized Carbonyls
Brodsky, B. H.; Du Bois, J.
Org. Lett. 2004, 6, 2619–2621.
Rh-Catalyzed Amination of Ethereal α-C–H Bonds: A Versatile Strategy for the Synthesis of Complex Amines
Williams Fiori, K.; Fleming, J. J.; Du Bois, J.
Angew. Chem. Int. Ed. 2004, 43, 4349–4352.
Expanding the Scope of C–H Amination Through Catalyst Design
Espino, C. G.; Williams Fiori, K.; Kim, M.; Du Bois, J.
J. Am. Chem. Soc. 2004, 126, 15378–15379.
2003
Novel Iminium Ion Equivalents Prepared Through C–H Oxidation for the Stereocontrolled Synthesis of Functionalized Propargylic Amine Derivatives
Fleming, J. J.; Williams Fiori, K.; Du Bois, J.
J. Am. Chem. Soc. 2003, 125, 2028–2029.
A Stereoselective Synthesis of (–)-Tetrodotoxin
Hinman, A.; Du Bois, J.
J. Am. Chem. Soc. 2003, 125, 11510–11511.
Stereochemical Models for Rh-Catalyzed Amination Reactions of Chiral Sulfamates
Wehn, P. M.; Lee, J.; Du Bois, J.
Org. Lett. 2003, 5, 4823–4826.
2002
Stereoselective Organozinc Addition Reactions to 1,2–Dihydropyrans for the Assembly of Complex Pyran Structures
Steinhuebel, D. P.; Fleming, J. J.; Du Bois, J.
Org. Lett. 2002, 4, 293–295.
Enantioselective Synthesis of the Bromopyrrole Alkaloids Manzacidin A and C by Stereospecific C–H Bond Oxidation
Wehn, P. M.; Du Bois, J..
J. Am. Chem. Soc. 2002, 124, 12950–12951
A Unique and Highly Efficient Method for Catalytic Olefin Aziridination
Guthikonda, K.; Du Bois, J.
J. Am. Chem. Soc. 2002, 124, 13672–13673.
2001
A Rh-Catalyzed C–H Insertion Reaction for the Oxidative Conversion of Carbamates to Oxazolidinones
Espino, C. G.; Du Bois, J.
Angew. Chem., Int. Ed. Engl. 2001, 40, 598–600.
Synthesis of 1,3–Difunctionalized Amine Derivatives through Selective C–H Bond Oxidation
Espino, C. G.; Wehn, P. M.; Chow, J.; Du Bois, J.
J. Am. Chem. Soc. 2001, 123, 6935–6936.