2017

Mack, J. B. C. M.; Gipson, J. D.; Du Bois, J; Sigman, M. S. Ruthenium-Catalyzed C-H Hydroxylation in Aqueous Acid Enables Selective Functionalization of Amine Derivatives. J. Am. Chem. Soc. 2017, ASAP.

2016

Sathyamoorthi, S.; Du Bois, J. Copper-Catalyzed Oxidative Cyclization of Carboxylic AcidsOrg. Lett. 201618, 6308-6311.

Logan, M. M.; Toma, T.; Thomas-Tran, R.; Du Bois, J. Asymmetric Synthesis of Batrachotoxin: Enantiomeric Toxins Show Functional Divergence against NavScience 2016354, 865-869.

Toma, T.; Logan, M. M.; Menard, F.; Devlin, A. S.; Du Bois, J. Inhibition of Sodium Ion Channel Function with Truncated Forms of BatrachotoxinACS Chem. Neruosci. 20167, 1463-1468.

Moretti, R. A.; Du Bois, J.; Stack, T. D. P. Manganese (II)/Picolinic Acid Catalyst System for Epoxidation of Olefins. Org. Lett. 201618, 2528.

Thomas-Tran, R.; Du Bois, J. Mutant cycle analysis with modified saxitoxins reveals specific interactions critical to attaining high-affinity inhibition of hNav1.7Proc. Natl. Acad. Sci. USA 2016113, 5856.

Mulcahy, J. V.; Walker, J. R.; Merit, J. E.; Whitehead, A.; Du Bois, J. Synthesis of the Paralytic Shellfish Poisons (+)-Gonyautoxin 2, (+)-Gonyautoxin 3, and (+)-11,11-Dihroxysaxitoxin. J. Am. Chem. Soc. 2016138, 5994.

Varela-Alvarez, A.;Yang, T.; Jennings, H.; Kornecki, K. P.; Macmillan, S. N.; Lancaster, K. M.; Mack, J. B. C.; Du Bois, J.; Berry, J. F.; Masaev, D. G. Rh2(II,III) Catalysts with Chelating Carboxylate and Carboxamidate Supports: Electronic Structure and Nitrene Transfer Reactivity. J. Am. Chem. Soc. 2016138, 2327.

2015

Adams, A. M.; Du Bois, J.; Malik, H. A. Comparative Study of the Limitations in Atom-Transfer C-H OxidationsOrg. Lett. 201517, 6066.

Bedell, T. A.; Hone, G. A. B.; Du Bois, J.; Sorensen, E. J. An Expedient Synthesis of Maraviroc (UK-427,857) via C-H Functionalization. Tett. Lett. 201556, 3620.

2014

Olson, D. E.; Su, J. Y.; Roberts, D. A.; Du Bois, J. Vicinal Diamination of Alkenes under Rh-Catalysis. J. Am. Chem. Soc. 2014, 136, 13506.

Flender, C.; Adams, A. M.; Roizen, J. L.; McNeil, E.; Du Bois, J.; Zare, R. N. Speciation and Decomposition Pathways of Ruthenium Catalysts used for Selective C-H HydroxylationChem. Sci. 2014, 5, 3309.

Thottumkara, A. P.; Parsons, W. H.; Du Bois, J. Saxitoxin. Angew. Chem. Int. Ed. 2014, 53 (23), 5760-5784.

Eberlin, L. S.; Mulcahy, J. V.; Tzabazis, A.; Zhang, J.; Liu, H.; Logan, M. M.; Roberts, H. J.; Lee, G. K; Yeomans, D. C.; Du Bois, J.; Zare, R. N. Visualizing Dermal Permeation of Sodium Channel Modulators by Mass Spectrometric Imaging J. Am. Chem. Soc.2014, 136 (17), 6401-6405.

Bess, E. N.; DeLuca, R. J.; Tindall, D. J.; Oderinde, M. S.; Roizen, J. L.; Du Bois, J.; Sigman, M. S.  Analyzing Site Selectivity in Rh2(esp)2-Catalyzed Intermolecular C-H Amination Reactions.  J. Am. Chem. Soc.2014136 (15), 5783-5789.

Malik, H. A.; Taylor, B. L. H.; Kerrigan, J. R.; Grob, J. E.; Houk, K.; Du Bois, J.; Hamann, L.; Patterson, A. W.  Non-Directed Allylic C-H Acetoxylation in the Presence of Lewis Basic Heterocycles.  Chem. Sci.2014, 5, 2352-2361.

Adams, A. M.; Du Bois, J.  Organocatalytic C–H hydroxylation with Oxone® enabled by an aqueous fluoroalcohol solvent system.  Chem. Sci.20145, 656-659.

2013

Hoehne, A.; Behera, D.; Parsons, W. H.; James, M. L.; Shen, B.; Borgohain, P.; Bodapati, D.; Prabhakar, A.; Gambhir, S. S.; Yeomans, D. C.; Biswal, S. Chin, F. T.; Du Bois, J.  A 18F-Labeled Saxitoxin Derivative for in Vivo PET-MR Imaging of Voltage-Gated Sodium Channel Expression Following Nerve Injury.  J. Am. Chem. Soc.2013135, 18012-18015.

Chen, J. K.; Du Bois, J.; Glenn, J.; Herschlag, D.; Khosla, C.  The Stanford Institute for Chemical Biology.  ACS Chem. Biol.20138, 1860-1861.

Roizen, J. L.; Zalatan, D. N.; Du Bois, J.  Selective Intermolecular Amination of C–H Bonds at Tertiary Carbon Centers.  Angew. Chem. Int. Ed.2013, 52, 11343-11346.

Parsons, W. H.; Du Bois, J.  Maleimide Conjugates of Saxitoxin as Covalent Inhibitors of Voltage-Gated Sodium Channels.  J. Am. Chem. Soc.2013, 135, 10582-10585.

Thottumkara, A. P.; Kurokawa, T.; Du Bois, J.  Carbocyclization of Unsaturated Thioesters under Palladium Catalysis.  Chem. Sci.2013, 4, 2686-2689.  

Devlin, A. S.; Du Bois, J. Modular Synthesis of the Pentacyclic Core of Batrachotoxin and Select Batrachotoxin Analogue Designs. Chem. Sci., 2013, 4, 1059-1063.

2012

Olson, D. E.; Roberts, D. A.; Du Bois, J.  Synthesis of Differentially Substituted 1,2-Diamines through Advances in C-H Amination Technology.  Org. Lett.201214, 6174-6177.  

Howery, A. E; Elvington, S.; Abraham, S. J.; Choi, K.-H.; Philips, S.; Ryan, C. M.; Sanford, R. L.; Simpson-Dworschak, S.; Almqvist, J.; Tran, K.; Chew, T. A.; Zachariae, U.; Andersen, O. S.; Whitelegge, J.; Matulef, K.; Du Bois, J.; Maduke, M. A Designed Inhibitor of a CLC Antiporter Blocks Function Through a Unique Binding Mode. Chem. Biol., 2012, 19, 1460-1470.

Perry, R. H.; Cahill III, T. J.; Roizen, J. L.; Du Bois, J.; Zare, R. N. Capturing Fleeting Intermediates in a Catalytic C–H Amination Reaction Cycle. Proc. Natl. Acad. Sci. USA, 2012, 109, 18295-18299.

Walker, J. R.; Novick, P.; Parsons, W. A.; McGregor, M.; Zablocki, J.; Pande, V. S.; Du Bois, J. Marked Difference in Saxitoxin and Tetrodotoxin Affinities for the Human Nociceptive Voltage-gated Sodium Channel (NaV1.7). Proc. Natl. Acad. Sci. USA, 2012, 109, 18102-18107.

Ondrus, A. E.; Lee, H.-l. D.; Iwanaga, S.; Parsons, W. H.; Andresen, B. M.; Moerner, W. E.; Du Bois, J. Fluorescent Saxitoxins for Live Cell Imaging of Voltage-gated Sodium Ion Channels Beyond the Optical Diffraction Limit. Chem. Biol., 2012, 19, 902-912.

Roizen, J. L.; Harvey, M. E.; Du Bois, J. Metal-Catalyzed Nitrogen-Atom Transfer Methods for the Oxidation of Aliphatic C–H Bonds. Acc. Chem. Res., 2012, 45, 911-922.

McNeill, E.; Du Bois, J. Catalytic C–H Oxidation by a Triazamacrocyclic Ruthenium Complex. Chem. Sci., 2012, 3, 1810-1813.

2011

Harvey, M. E.; Musaev, D. G.; Du Bois, J. A Diruthenium Catalyst for Selective, Intramolecular Allylic C–H Amination: Reaction Development and Mechanistic Insight Gained Through Experiment and Theory. J. Am. Chem. Soc., 2011, 133, 17207-17216.

Olson, D. E.; Maruniak, A.; Malhotra, S.; Trost, B. M.; Du Bois, J. Synthesis and Reactivity of Unique Heterocyclic Structures en route to Substituted Diamines. Org. Lett., 2011, 13, 3336-3339.

Du Bois, J. Rhodium-Catalyzed C–H Amination – An Enabling Method for Chemical Synthesis. Org. Process Res. Dev., 2011, 15, 758-762.

2010

McNeill, E.; Du Bois, J. Ruthenium-Catalyzed Hydroxylation of Unactivated 3° C–H Bonds. J. Am. Chem. Soc., 2010, 132, 10202-10204.

Zalatan, D. N.; Du Bois, J. Metal-Catalyzed Oxidations of C–H to C–N Bonds. Top. Curr. Chem., 2010, 292, 347-378.

2009

Andresen, B. A.; Du Bois, J. De Novo Synthesis of Modified Saxitoxins for Sodium Ion Channel Study. J. Am. Chem. Soc., 2009, 131, 12524-12525.

Zalatan, D. N.; Du Bois, J. Understanding the Differential Performance of Rh2(esp)2 as a Catalyst for C–H Amination. J. Am. Chem. Soc., 2009, 131, 7558-7559.

Litvinas, N. D.; Du Bois, J. C–H Hydroxylation Using a Heterocyclic Catalyst and Aqueous H2O2. Angew. Chem. Int. Ed., 2009, 48, 4513-4516.

Wehn, P. M.; Du Bois, J. A Stereoselective Synthesis of the Bromopyrrole Natural Product (–)-Agelastatin A. Angew. Chem. Int. Ed., 2009, 48, 3802-3805.

Kurokawa, T.; Kim, M.; Du Bois, J. Synthesis of 1,3-Diamines Through Rhodium-Catalyzed C–H Insertion. Angew. Chem. Int. Ed., 2009, 48, 2777-2779.

Trost, B. M.; Malhotra, S.; Olson. D. E.; Maruniak, A.; Du Bois, J. Asymmetric Synthesis of Diamine Derivatives via Sequential Palladium and Rhodium Catalysis. J. Am. Chem. Soc., 2009, 131, 4190-4191.

Williams Fiori, K.; Espino, C. G.; Brodsky, B. H.; Du Bois, J. A Mechanistic Analysis of the Rh-Catalyzed Intramolecular C–H Amination Reaction. Tetrahedron (special edition honoring Tetrahedron Young Investigator), 2009, 65, 3042-3051.

Zaltan, D. N.; Du Bois, J. Oxidative Cyclization of Sulfamate Esters Using NaOCl – A Metal-Mediated Hoffman-Löffler-Freytag Reaction. Synlett (cluster on C–H activation), 2009, 143-146.

2008

Mulcahy, J. V.; Du Bois, J. A Stereoselective Synthesis of (+)-Gonyautoxin 3. J. Am. Chem. Soc., 2008, 130, 12630-12631.

Olson, D. E.; Du Bois, J. Catalytic C–H Amination for the Preparation of Substituted 1,2-Diamines. J. Am. Chem. Soc., 2008, 130, 11248-11249.

Zalatan, D. N.; Du Bois, J. A Chiral Rhodium Carboxamidate Catalyst for Enantioselective C–H Amination. J. Am. Chem. Soc., 2008, 130, 9220-9221.

Matulef, K.; Howery, A. E.; Tan, L.; Kobertz, W. R.; Du Bois, J.; Madduke, M. Discovery of Potent CLC Chloride Channel Inhibitors. ACS Chem. Bio., 2008, 3, 419-428.

2007

Conrad, R. M.; Du Bois, J. C–H Amination in Synthesis: An Approach to the Assembly of the B/C/D Ring System of Aconitine. Org. Lett., 2007, 9, 5465-5468.

Wolckenhauer, S. A.; Devlin, A. S.; Du Bois, J. γ-Sultone Formation Through Rh-Catalyzed C–H Insertion. Org. Lett., 2007, 9, 4363-4366.

Fleming, J. J.; McReynolds, M. D; Du Bois, J. (+)-Saxitoxin: A First and Second Generation Stereoselective Synthesis. J. Am. Chem. Soc., 2007, 129, 9964-9975.

Williams Fiori, K.; Du Bois, J. Catalytic Intermolecular Amination of C–H Bonds: Method Development and Mechanistic Insights. J. Am. Chem. Soc., 2007, 129, 562-568.

2006

Brodsky, B. H.; Du Bois, J. Entrapment of a Dirhodium Tetracarboxylate Unit Inside the Aromatic Bowl of a Calix[4]arene: Unique Catalysts for C–H Amination. Chem. Comm., 2006, 4715-4717.

Guthikonda, K.; Wehn, P. M.; Caliando, B. J.; Du Bois, J. Rh-Catalyzed Alkene Oxidation: A Highly Efficient Process for Preparing N-Alkoxysulfonyl Aziridines. Tetrahedron (special edition honoring Tetrahedron Young Investigator), 2006, 62, 11331-11342.

Fleming, J. J.; Du Bois, J. A Synthesis of (+)-Saxitoxin. J. Am. Chem. Soc., 2006, 128, 3926-3927.

Kim, M.; Mulcahy, J. V.; Espino, C. G.; Du Bois, J. Expanding the Substrate Scope of C–H Amination Reactions: Oxidative Cyclization of Urea and Guanidine Derivatives. Org. Lett., 2006, 8, 1073-1076.

2005

Brodsky, B. H.; Du Bois, J. Oxaziridine-Mediated Hydroxylation of Unactivated 3° C–H Bonds Using Hydrogen Peroxide. J. Am. Chem. Soc., 2005, 127, 15391-15393.

Wehn, P. M.; Du Bois, J. Exploring New Uses for C–H Amination: Ni-Catalyzed Cross Coupling of Cyclic Sulfamates. Org. Lett., 2005, 7, 4685-4688.

Du Bois, J. Rhodium Catalyzed C–H Amination: Versatile Methodology for the Selective Preparation of Amines and Amine Derivatives. Chemtracts. Org. Chem., 2005, 18, 1-13.

Espino, C. G.; Du Bois, J. In Modern Rhodium-Catalyzed Organic Reactions, Ed.: P. A. Evans, Wiley-VCH Verlag, Weinheim, 2005, pp 379-416.

2004

Espino, C. G.; Williams Fiori, K.; Kim, M.; Du Bois, J. Expanding the Scope of C–H Amination Through Catalyst Design. J. Am. Chem. Soc., 2004, 126, 15378-15379.

Williams Fiori, K.; Fleming, J. J.; Du Bois, J. Rh-Catalyzed Amination of Ethereal α-C–H Bonds: A Versatile Strategy for the Synthesis of Complex Amines. Angew. Chem. Int. Ed., 2004, 43, 4349-4352.

Brodsky, B. H.; Du Bois, J. Deacylative Oxidation Strategy for the Preparation of -Functionalized Carbonyls. Org. Lett., 2004, 6, 2619-2621.

2003

Wehn, P. M.; Lee, J.; Du Bois, J. Stereochemical Models for Rh-Catalyzed Amination Reactions of Chiral Sulfamates. Org. Lett., 2003, 5, 4823-4826.

Hinman, A.; Du Bois, J. A Stereoselective Synthesis of (–)-Tetrodotoxin. J. Am. Chem. Soc., 2003, 125, 11510-11511.

Fleming, J. J.; Williams Fiori, K.; Du Bois, J. Novel Iminium Ion Equivalents Prepared Through C–H Oxidation for the Stereocontrolled Synthesis of Functionalized Propargylic Amine Derivatives. J. Am. Chem. Soc., 2003, 125, 2028-2029.

2002

Guthikonda, K.; Du Bois, J. A Unique and Highly Efficient Method for Catalytic Olefin Aziridination. J. Am. Chem. Soc., 2002, 124, 13672-13673.

Wehn, P. M.; Du Bois, J. Enantioselective Synthesis of the Bromopyrrole Alkaloids Manzacidin A and C by Stereospecific C–H Bond Oxidation. J. Am. Chem. Soc., 2002, 124, 12950-12951.

Steinhuebel, D. P.; Fleming, J. J.; Du Bois, J. Stereoselective Organozinc Addition Reactions to 1,2–Dihydropyrans for the Assembly of Complex Pyran Structures. Org. Lett., 2002, 4, 293–295.

2001

Espino, C. G.; Wehn, P. M.; Chow, J.; Du Bois, J. Synthesis of 1,3–Difunctionalized Amine Derivatives through Selective C–H Bond Oxidation. J. Am. Chem. Soc., 2001, 123, 6935–6936.

Espino, C. G.; Du Bois, J. A Rh-Catalyzed C–H Insertion Reaction for the Oxidative Conversion of Carbamates to Oxazolidinones. Angew. Chem., Int. Ed. Engl., 2001, 40, 598–600.